ε-Poly(L-lysine)-Based Hydrogels with Fast-Act...

AbstractBacterial infections and the associated morbidity and mortality due to bacterial pathogens in wounds and medical implants have been increasing as most of current coatings cannot fulfill all the requirements including excellent intrinsically antibacterial activity, low cytotoxicity, and favorable physical properties. Herein, we present a kind of antibacterial hydrogel based on the ε...[详细]

2018-05-21

Polymer Vesicles: Modular Platforms for Cancer ...

Abstract:As an emerging field that is receiving an increasing amount of interest, theranostics is becoming increasingly important in the field of nanomedicine. Among the various smart platforms that have been proposed for use in theranostics, polymer vesicles (or polymersomes) are among the most promising candidates for integration of designated functionalities and modalities. Here, ...[详细]

2018-03-25

Synthesis, Self-Assembly and Biomedical Applica...

Abstract:Antimicrobial peptides (AMPs) have been attracting much attention due to their excellent antimicrobial efficiency and low rate in driving antimicrobial resistance (AMR) which has been increasing globally to alarming levels. Conjugation of AMPs into functional polymers not only preserves excellent antimicrobial activities but reduces the toxicity and offers more functionalities,...[详细]

2018-03-15

Polymer Nanodisks by Collapse of Nanocapsules

Abstract:It is an important challenge to make disk-like polymeric nanostructures. Herein we report a facile method for preparing polymer nanodisks by self-collapse of nanocapsules self-assembled from a statistical copolymer after partial hydrolysis. We find that partial hydrolysis of the statistical copolymer is crucial for the formation of nanodisks as it affords a suitable rigidity fo...[详细]

2018-01-23

Efficient Removal of Polycyclic Aromatic Hydroc...

Abstract: It is an important challenge to effectively remove environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs), dyes and heavy metal ions at a low cost. Herein, we present a multifunctional homopolymer vesicle self-assembled from a scalable homopolymer, poly(amic acid) (PAA) at room temperature. The vesicle can efficiently eliminate PAHs, cationic dyes and ...[详细]

2017-12-06

Highly Effective Antibacterial Vesicles Based o...

Abstract： It is an important challenge for bone repair to effectively deliver growth factors and at the same time to prevent and cure inflammation without obvious pathogen resistance. We designed a kind of antibacterial peptide-mimetic alternating copolymers (PMACs) to effectively inhibit and kill both Gram-positive and Gram-negative bacteria. The minimum inhibition concentrations (MICs) ...[详细]

2017-10-11

Antibacterial hydrogels incorporated with poly(...

Abstract:Antibacterial hydrogels with durable and efficient antibacterial ability are promising biomedical materials. Copolymers with poly(amino acid) segments may provide unique functionalities for hydrogels. Herein, polycaprolactone-block-poly(glutamic acid) (PCL-b-PGA) was synthesized by ring-opening polymerization (ROP) and subsequently self-assembled into vesicles. Furthermore, ant...[详细]

2017-09-13

Hydrogel scaffolds for differentiation of adipo...

Abtract:Natural extracellular matrices (ECMs) have been widely used as a support for the adhesion, migration, differentiation, and proliferation of adipose-derived stem cells (ADSCs). However, poor mechanical behavior and unpredictable biodegradation properties of natural ECMs considerably limit their potential for bioapplications and raise the need for different, synthetic scaffolds. H...[详细]

2017-08-17

EpCAM-antibody-conjugated polymersomes for canc...

AbstractCancer stem cells (CSCs) have the capability to initiate tumor, to sustain tumor growth, to maintain the heterogeneity of tumor, and are closely linked to the failure of chemotherapy due to their self-renewal and multilineage differentiation capability with an innate resistance to cytotoxic agents [1]. Polymersomes (polymer vesicles) are excellent delivery vehicles for anticance...[详细]

2017-08-10

Sugar-Breathing Glycopolymersomes for Regulatin...

Abstract：Diabetes mellitus is a chronic, life-threatening illness that affects people of every age and ethnicity. It is a long-term pain for those who are affected and must regulate their blood glucose level by frequent subcutaneous injection of insulin every day. Herein, we propose a noninsulin and antidiabetic drug-free strategy for regulating blood glucose level by a nanosized “sug...[详细]

2017-05-16

Diverse Applications of Nanomedicine

Abstract:The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological...[详细]

2017-03-14

Synthesis and Characterization of Thermo-Respo...

Abstract: It is an important challenge to balance the degradability and stability of polymer vesicles. We report a thermo-responsive vesicle based on poly[(N-isopropyl acrylamide-stat-7-(2- methacryloyloxyethoxy)-4-methylcoumarin)-b-(L-glutamic acid)] [P(NIPAM45-stat-CMA5)-b-PGA42] diblock copolymer, which was synthesized by reversible addition fragmentation chain...[详细]

2017-01-16