- 学术论文
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Bioabsorbable Zwitterionic Hydrogels Achieving ...
AbstractCell adhesion plays a crucial role in determining the functionality of hydrogel-based culture platforms or implants and is commonly mediated by adhesive proteins. However, nonspecific protein adhesion is prone to causing inflammatory response in vivo. Traditional hydrogels are usually either pro- or anticell/protein adhesion simultaneously. To address this dilemma, a series of novel bio...[详细]
2023-11-14 -
An Antibacterial Polypeptide Coating Prepared b...
AbstractDelayed implant-associated infection is an important challenge, as the treatment involves a high risk of implant replacement. Mussel-inspired antimicrobial coatings can be applied to coat a variety of implants in a facile way, but the adhesive 3,4-dihydroxyphenylalanine (DOPA) group is prone to oxidation. Therefore, an antibacterial polypeptide copolymer poly(Phe7-stat-Lys10)-b-polyTyr3...[详细]
2023-05-31 -
Vanillin-Based Degradable Polyurethane Thermose...
AbstractPolyurethanes are widely used polymeric materials, but they are rarely biorenewable and degradable. Although some previously reported bio-based polyurethanes exhibit good thermal and mechanical properties, their bio-content is usually low, resulting from the only replacement of the diol monomer instead of the whole diol/diisocyanate pairs. In addition, traditional polyurethanes are ofte...[详细]
2023-05-26 -
In Situ Enzyme-Induced Self-Assembly of Antimic...
AbstractAntimicrobial peptides (AMPs) with dual intrinsic antibacterial and antioxidative functions have emerged as promising choice to cure infected wound. However, the most widely applied approach to endow AMPs with antioxidative function is to combine with antioxidative moieties, which may affect the spatial structure and physiological stability of AMPs. Herein, a new type of AMPs with inher...[详细]
2023-03-12 -
Quantifiable Relationship Between Antibacterial...
AbstractPhysical disruption is an important antibacterial means as it is lethal to bacteria without spurring antimicrobial resistance. However, it is very challenging to establish a quantifiable relationship between the antibacterial efficacy and physical interactions such as mechanical and electrical forces. Herein, titanium nitride (TN) nanowires with adjustable orientations and capacitances ...[详细]
2023-03-05 -
Stimuli-Responsive Hydrogels for Cancer Immunot...
AbstractImmunotherapy plays an important role in cancer treatment by activating or suppressing the immune system. However, there are still a series of challenges to overcome regarding the delivery vehicles of immunotherapeutic agents and their effective activation at tumor sites. Meanwhile, owing to their well-hydrated environment and capability of immobilizing biological cargos, hydrogels in c...[详细]
2023-02-17 -
Intestine Enzyme-responsive Polysaccharide-base...
AbstractImatinib has been widely used as a selective kinase inhibitor for treating a variety of cancers, and this molecule is very hydrophobic so it is usually modified with mesylate salt in clinic to increase bioavailability. However, pH-dependent aqueous solubility and relatively high dosage of imatinib mesylate greatly reduce the clinical outcomes. To solve this problem, we developed an inte...[详细]
2022-12-22 -
Oxygen-generating polymer vesicles for enhanced...
AbstractThe efficacy of sonodynamic therapy (SDT) is often limited by the insolubility of sonosensitizers and unfavorable hypoxia tumor microenvironment. To meet this challenge, an oxygen-generating polymer vesicle is developed to achieve enhanced SDT. The hydrophilic coronas and the hydrophobic membrane of polymer vesicles can function as different modules for the simultaneous delivery of mang...[详细]
2022-12-22 -
A polypeptide coating for preventing biofilm on...
AbstractAging population has been boosting the need for orthopedic implants. However, biofilm has been a major obstacle for orthopedic implants due to its insensitivity to antibiotics and tendency to drive antimicrobial resistance. Herein, an antibacterial polypeptide coating with excellent in vivo adhesive capacity was prepared to prevent implants from forming biofilms and inducing acquire...[详细]
2022-12-13 -
Drug delivery approaches for enhanced antibiofi...
AbstractBiofilms have attracted increasing attention in recent years. Many bacterial infections are associated with biofilm formation. A bacterial biofilm is an aggregated membrane-like substance that is composed of a large number of bacteria and their secreted extracellular polymeric substances. The traditional antibiofilm approaches, such as chemotherapy based on antibiotics, are often ineffe...[详细]
2022-12-07