Tryptophan-Modulated Nanoscale Metal−Organic F...

AbstractOwing to the high surface area and porosity, metal− organic frameworks (MOFs) could be utilized as both nanocarriers of biopharmaceuticals and nanoreactors to organize cascade biological reactions with great potential in cancer treatment. However, nanoscale MOFs suitable for biomedical applications rely on harsh preparation conditions. Here, we utilized tryptophan to modulate the morph...[详细]

2022-12-06

Chirality-controlled polymerization-induced sel...

AbstractRecent studies have shown that biodegradable nanoparticles can be efficiently prepared with polymerization of N-carboxyanhydrides-induced self-assembly (NCA-PISA). However, thus far, the effect of chiral monomer ratio on such NCA-PISA formulations and the resulting nanoparticles has not yet been fully explored. Herein, we show, for the first time, that the morphology, secondary structur...[详细]

2022-11-24

Ultrasound-Responsive Peptide Nanogels to Balan...

AbstractA series of biological barriers need to be overcome for therapeutic nanocarriers accumulating at the tumor site and uptaken by cancer cells. One strategy is to construct switchable nanocarriers to meet the conflicting requirements for various physiology environments. In this work, besides widely studied endogenous stimuli-responsiveness, an exogenous ultrasound responsiveness was additi...[详细]

2022-04-28

Lateral growth of cylinders

AbstractThe precise control of the shape, size and microstructure of nanomaterials is of high interest in chemistry and material sciences. However, living lateral growth of cylinders is still very challenging. Herein, we propose a crystallization-driven fusion-induced particle assembly (CD-FIPA) strategy to prepare cylinders with growing diameters by the controlled fusion of spherical micelles ...[详细]

2022-04-26

Intracellular Self-Assembly of Peptides to Indu...

AbstractBiosynthesis has been a diverse toolbox to develop bioactive molecules and materials, especially for fabricating modified peptides and their assemblies induced by enzymes. Although desired chemical structures and nanoarchitectures have been achieved, the subsequent interferences of peptide assemblies with organelles and the cellular pathways still remain unsolved important challenges. H...[详细]

2022-04-03

Fully Bio-Based High-Performance Thermosets wit...

Abstract：Thermosets are important commodity polymeric materials, but they are rarely biorenewable and recyclable. Although some previously reported bio-based aromatic thermosets with a high aromatic content have good thermal/mechanical properties, the mechanical properties of fully bio-based vitrimers are relatively poor owing to low aromatic contents. To address this important issue, vanillin-b...[详细]

2022-01-05

Mitochondrial-targeting nanoprodrugs to mutuall...

Abstract：Abnormal energy metabolism is one of the hallmarks of cancer and closely linked to therapy resistance. However, existing metabolic inhibitors suffer from inefficient cell enrichment and therapeutic effects. In this work, we developed an effective strategy to mutually reinforce the metabolic inhibition and autophagy for enhanced tumor killing efficacy and combating resistant cancer. Firs...[详细]

2021-11-03

Polymersome Wound Dressing Spray Capable of Bac...

Abstract：Diabetic wounds are difficult to heal due to recurrent bacterial infection, decreased proliferation, and migration of epidermal and endothelial cells. This is related to impaired leukocyte function and low blood concentrations of H2S in diabetic patients. Herein, an antibacterial polymersome-based wound dressing spray was demonstrated for complete diabetic wound healing. The designed po...[详细]

2021-10-14

Bone-Targeting Polymer Vesicles for Effective T...

Abstract:With the aging of the population, postmenopausal osteoporosis becomes increasingly widespread and severe as fractures caused by osteoporosis may lead to permanent disabilities and even death. Inspired by extracellular vesicles that participate in bone remodeling, we present a biomimicking polymer vesicle for bone-targeted β-estradiol (E2) delivery. This vesicle is self- assembled from ...[详细]

2021-09-18

Giant Polymer Vesicles with a Latticelike Membr...

Abstract：Hierarchical self-assembly offers great possibilities to mimic biological systems with finely arranged complex structures. Herein, we demonstrate the preparation and formation mechanism of an unusual giant polymer vesicle with a latticelike membrane (GVLM). This GVLM is formed by fusion-induced particle assembly (FIPA) of small vesicles that are self-assembled from poly(ethylene oxide)...[详细]

2021-07-21

Breaking the Corona Symmetry of Vesicles

Abstract：It is very challenging to completely break the corona symmetry of polymer vesicles as usually their inner and outer coronas have the same constituents. Herein, we propose a novel micelle-to-vesicle strategy to achieve this goal. First, a poly(ethyleneoxide)113-b-poly[N-isopropylacrylamide45-stat-7-(2-methacryloyloxyethoxy)-4-methylcoumarin10]-b-poly(2-(diethylamino)ethylmethacrylate)28[...[详细]

2021-06-01

Combined Antioxidant–Antibiotic Treatment for ...

Abstract：Infected diabetic wounds are difficult to heal due to high reactive oxygen species (ROS) concentrations and recurrent infections. Such wounds can easily deteriorate into a diabetic ulcer, a chronic diabetic complication with a very high mortality rate. Herein, we propose a combined antioxidant–antibiotic therapy based on poly(ε-caprolactone)-block-poly(glutamic acid) polymer vesicle ...[详细]

2021-04-22