Breaking the Corona Symmetry of Vesicles

Abstract：It is very challenging to completely break the corona symmetry of polymer vesicles as usually their inner and outer coronas have the same constituents. Herein, we propose a novel micelle-to-vesicle strategy to achieve this goal. First, a poly(ethyleneoxide)113-b-poly[N-isopropylacrylamide45-stat-7-(2-methacryloyloxyethoxy)-4-methylcoumarin10]-b-poly(2-(diethylamino)ethylmethacrylate)28[...[详细]

2021-06-01

Combined Antioxidant–Antibiotic Treatment for ...

Abstract：Infected diabetic wounds are difficult to heal due to high reactive oxygen species (ROS) concentrations and recurrent infections. Such wounds can easily deteriorate into a diabetic ulcer, a chronic diabetic complication with a very high mortality rate. Herein, we propose a combined antioxidant–antibiotic therapy based on poly(ε-caprolactone)-block-poly(glutamic acid) polymer vesicle ...[详细]

2021-04-22

Intramolecular Cyclization-Induced Crystallizat...

Abstract：We propose a new concept of intramolecular cyclization-induced crystallization-driven self-assembly (ICI-CDSA) based on an amorphous poly(amic acid) (PAA). Nanobundles with high crystallinity were prepared via CDSA that was thermally induced by the imidization reaction of PAA as the crystallizable polyimide segments were introduced into its back-bone. With the increase of the initial co...[详细]

2020-12-03

Renoprotective Angiographic Polymersomes

Abstract：Computed tomography (CT) angiography is powerful for the diagnosis of vascular diseases. Unfortunately, this method usually requires a high dosage of iodinated contrast agents, which can lead to severe elevation of reactive oxygen species (ROS) levels within kidneys. This causes oxidative stress, apoptosis, and hence contrast-induced nephropathy (CIN), a leading cause of iatrogenic rena...[详细]

2020-10-02

Principles and Characteristics of Polymerizatio...

Abstract：A chemical reaction that drives a physical polymer self-assembly process: PISAcombines block copolymer synthesis and nanoparticle formation efficiently at high polymer concentrations. Various nanoparticle morphologies (such as: spheres, worms and vesicles) can readily be prepared in polar and non-polar media. PISA has been well-developed in combination with Reversible Addition-Fragmenta...[详细]

2020-09-29

Bone-targeting polymer vesicles for simultaneou...

Abstract：We present a bone-targeting polymer vesicle with excellent single photon emission computed tomography/computed tomography (SPECT/CT) imaging capabilities and high antitumor drug delivery efficiencies as an integrated platform for the simultaneous diagnosing and treatment of malignant bone tumors. This polymer vesicle is self-assembled from poly(ε-caprolactone)67-b-poly[(l-glutamic aci...[详细]

2020-08-27

Design principles, synthesis and biomedical app...

Abstract：Inspired by cell membrane structures, synthetic polymer vesicles caused great expectations for the preparation of biomedicine for decades. However, in contrast to bio-membranes, which consist of inhomogeneous features, conventional synthetic polymer vesicles usually consist of a homogeneous membrane which is purely made out of hydrophobic components. This significantly limited t...[详细]

2020-07-26

Effective treatment of drug-resistant lung canc...

Abstract：Cisplatin resistance is a daunting obstacle in cancer therapy and one of the major causes for treatment failure due to the inadequate drug activity and apoptosis induction. To overcome cisplatin resistance, we proposed a multifunctional nanogel (designated as Valproate-D-Nanogel) capable of reactivating cisplatin and enhancing early apoptosis. This Valproate-D-Nanogel was prepar...[详细]

2020-07-26

Two Principles for Polymersomes with Ultrahigh ...

Abstract：Herein, two novel principles are proposed for the judicious design of polymersomes with ultrahigh loading efficiencies for various biomacromolecules: (1) acid-induced adsorption (AIA) for proteins and (2) affinity-enhanced attraction (AEA) for nucleic acids. The former principle (AIA) is assisted by the triazole group within the polymersome membrane. The latter principle (AEA)...[详细]

2020-05-14

Tetrapod Polymersomes

Abstract: Hollow nanoparticles such as polymersomes have promising potentials in many fields. However, the design and construction of higher-order polymersomes with precisely controlled spatial compartments is still very challenging. Herein, we report a unique tetrapod polymersome that is evolved via precisely controlled fusion of four traditional spherical polymersomes that are se...[详细]

2020-03-12

Poly(ε-caprolactone)-Polypeptide Copolymer Mic...

Abstract: Bacterial infection is a major threat to human health, and can cause several diseases including gastroenteritis, influenza, tetanus, and tuberculosis. As conventional antibiotic treatment may cause various undesirable effects such as stomach disorder and bacterial resistance, it is necessary to improve the antibacterial efficiency of antibiotics. Here, we synthesized a peptide...[详细]

2019-12-20

Superparamagnetic nanoparticles for biomedical ...

Abstract: Recent advances in the development and biological applications of polymeric nanoparticles embedded with superparamagnetic iron oxide nanoparticles (SPIONs) are summarized. Novel superparamagnetic polymeric nanoparticles are prepared, including core-shell nanoparticles, superparamagnetic polymeric micelles and superparamagnetic polymersomes. They have potential for various ...[详细]

2019-12-20