Abstract

We present a bone-targeting polymer vesicle with excellent single photon emission computed tomography/computed tomography (SPECT/CT) imaging capabilities and high antitumor drug delivery efficiencies as an integrated platform for the simultaneous diagnosing and treatment of malignant bone tumors. This polymer vesicle is self-assembled from poly(ε-caprolactone)₆₇-b-poly[(l-glutamic acid)₆-stat-(l-glutamic acid-alendronic acid)₁₆] (PCL₆₇-b-P[Glu₆-stat-(Glu-ADA)₁₆]) directly in water without the aid of a cosolvent. SPECT/CT dynamically tracked the drug distribution in the bone tumor rabbit models, and the tumor size was significantly reduced from >2.0 cm³ to <0.6 cm³ over 11 days. The pathological analysis demonstrated obvious necrosis and apoptosis of the tumor cells. Overall, this bone-targeting polymer vesicle provides us with a new platform for the combination of real-time diagnosis and therapy of malignant bone tumors.

文章链接：Biomaterials 2021, 269, 120345.