Dual Corona Vesicles with Intrinsic Antibacteri...

Abstract: Periodontitis is a common disease caused by plaque biofilms, which are important pathogenic factors of many diseases and may be eradicated by antibiotic therapy. However, low dose antibiotic therapy is a complicated challenge for eradiating biofilms as hundreds (even thousands) of times higher concentrations of antibiotics are needed than killing planktonic bacteria. Polymer...[详细]

2019-10-05

Ring-Opening Polymerization of N-Carboxyanhydri...

Abstract: Polymerization-induced self-assembly (PISA) is regarded as one of the most important strategies in macromolecular nanotechnology, as it can create a wide range of nanoparticles at high concentrations and on a large scale. However, open-to-air PISA with biodegradable product is still a complicated challenge, as traditional PISA is usually carried out under oxygen-free condi...[详细]

2019-09-12

On the origin and regulation of ultrasound resp...

Abstract:Noninvasive ultrasound is more convenient and easily accessible for controlled drug delivery of polymeric nanoparticles than many other stimuli. However, controlled ultrasound responsiveness is rather challenging as the mechanism is still unclear. In this paper, we disclose the origin and the key regulating factors of ultrasound responsiveness of block copolymer nanoparticl...[详细]

2019-09-12

Ultrasound-Responsive Homopolymer Nanoparticles

AbstractNoninvasive ultrasound is a more effective strategy for on-demand drug delivery of polymeric nanoparticles than many other stimuli. However, the preparation of ultrasound-responsive homopolymer nanoparticles is still very challenging. In this paper, we disclose the regulating factors of ultrasound responsiveness of homopolymer nanoparticles and the disaggregation behavior of homopolymer...[详细]

2019-09-12

Controlling blood sugar levels with a glycopoly...

AbstractDiabetes mellitus is a group of metabolic disorders with lifelong high blood sugar levels. Patients with diabetes must give themselves shots of insulin and/or other medication every day, usually accompanying poor blood sugar control and patient compliance. To meet this important challenge, we propose a noninsulin and drug-free strategy for long-acting regulation of blood s...[详细]

2019-08-20

Preparation, application and perspective in pol...

Abstract聚合物囊泡是通过聚合物自组装构筑的纳米组装体，由于其独特的空腔-膜层-冠层结构，在生物医用等领域具有较好的应用前景，因此越来越受到研究者的关注。不同于传统的均相膜囊泡，非均相膜囊泡的膜层由不相容的组分构成，呈现出微相分离的特点，具有丰富的功能。但是目前还未提出非均相膜囊泡的概念，这限制了该领域的进一步发展。因此，有必要明确非均相膜聚合物囊泡的概念，并对该领域的研究进展进行系统的归...[详细]

2019-01-19

Nanobowls with controlled openings and interior...

AbstractAsymmetric nanoparticles such as nanobowls have promising potential in many fields due to their interior asymmetric cavities and specific concave structure. However, the fabrication of nanobowls and control over their openings and interior holes are still challenging. Herein we demonstrate a versatile strategy for preparing nanobowls with precisely controlled openings and interior h...[详细]

2018-11-21

Evolution of diverse higher-order membrane stru...

AbstractIt is an important challenge to create and reveal subtle higher-order membrane nanostructures of block copolymer vesicles by conventional transmission electron microscopy (TEM) due to the difficulty in trapping them. To solve this problem, a series of hydrolytically cross-linkable poly(ethylene oxide)-block-poly(3-(trimethoxysilyl)propyl methacrylate) (PEO-b-PTMSPMA) block c...[详细]

2018-11-08

Size and Shape Affects the Antimicrobial Activi...

AbstractCrystallization driven self‐assembly (CDSA) was utilized to prepare quaternized nanoparticles with spherical or platelet morphologies of different sizes to explore the effect of size and shape on their antibacterial activity. Small 2D platelets (< 1 µm) exhibited greater antibacterial activity than larger 2D platelets (ca. 4 µm), their corresponding spherical constructs, ...[详细]

2018-10-18

Polymersome-hydrogel composites with combined q...

AbstractWe present an antibacterial polymersome-hydrogel composite that combined advantages of both antimicrobial peptides and antibiotics. The polymersomes are self-assembled from poly(ε-caprolactone)-block-poly(lysine-stat-phenylalanine) [PCL-b-P(Lys-stat-Phe)], exhibiting long-acting intrinsic antibacterial capabilities against both Gram-positive and Gram-negative bacteria. In a...[详细]

2018-08-30

Plasmonic Vesicles with Tailored Collective Pro...

AbstractPlasmonic nanoparticle assemblies have been exhibiting unique collective properties absent in their individual counterparts. However, it is an important challenge to manipulate those properties due to the difficulty in controlling the arrangement and distance between plasmonic nanoparticles. Herein, we propose an alternative strategy for manipulating the distance between gold na...[详细]

2018-08-28

Dually Gated Polymersomes for Gene Delivery

AbstractAn ideal gene carrier requires an excellent gating system to efficiently load, protect, deliver and release environmentally sensitive nucleic acids on demand. Presented in this communication is a polymersome with a “boarding gate” and a “debarkation gate” in the membrane to complete the above important missions. This dually gated polymersome is selfassembled from a block cop...[详细]

2018-07-28