Abstract:          

 It is an important challenge to balance the degradability and stability of polymer vesicles. We report a thermo-responsive vesicle based on poly[(N-isopropyl acrylamide-stat-7-(2- methacryloyloxyethoxy)-4-methylcoumarin)-b-(L-glutamic acid)] [P(NIPAM₄₅-stat-CMA₅)-b-PGA₄₂] diblock copolymer, which was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization and ring-opening polymerization (ROP). The membrane of the vesicle consists of thermo-responsive PNIPAM and photo-cross-linkable PCMA. The PGA chains in the vesicle coronas can colloidally stabilize the vesicles in water and can be postfunctionalized for further applications. Transmission electron microscopy and dynamic light scattering studies confirmed the formation of vesicles. Overall, we prepared a new functional thermo-responsive vesicle based on polypeptide copolymers that may be used as nanocarriers for the facile loading of a range of molecules in future.            

文章链接： Acta Physico-Chimica Sinica 2017, 33, 656-660. (Cover of Issue 4, 2017)