Preparation and Antibacterial Mechanism Insight...

Abstract: Traditional antibiotics usually sterilize in chemical ways, which may lead to serious drug resistance. By contrast, peptide-based antibacterial materials are less susceptible to drug resistance. Herein we report the preparation of an antibacterial peptide-based copolymer micelle and the investigation of its membrane-penetration antibacterial mechanism by transmission electr...[详细]

2016-11-02

Hairy cylinders based on a coil-comb-coil copol...

Abstract Self-assembled complex structures with finely controlled arrangements are universal in biological systems but the corresponding formation mechanism usually remains unknown. Herein we report an example using fully synthetic copolymers with complex molecular structure and fuzzy hydrophilic/hydrophobic boundary to mimic multiple levels of self-assembly. We report the formation ...[详细]

2016-10-27

A superparamagnetic polymersome with extremely ...

Keywords MRI；Superparamagnetic iron oxide nanoparticles；Polymersome；Polymer vesicle；Antitumor drug delivery；Self-assemblyAbstract: Improving the relaxivity of magnetic resonance imaging (MRI) contrast agents is an important challenge for cancer theranostics. Herein we report the design, synthesis, characterization, theoretical analysis and in vivo tests of a super...[详细]

2016-10-15

Template-free fabrication of nitrogen-doped hol...

Abstract Presented in this article is the template-free fabrication of nitrogen-doped hollow carbon spheres (N-HCSs) as electrode materials for high-performance supercapacitors based on scalable homopolymer vesicles, which are self-assembled from an amphiphilic homopolymer, poly(amic acid) (PAA). This homopolymer can be massively produced by simple stepwise polymerization at room tem...[详细]

2016-06-29

Recent advances in magnetic hydrogels

Abstract Smart hydrogels that respond to magnetic fields have attracted increasing interest in recent years. This is as a result of their numerous potential applications such as tunable delivery vehicles, magnetic resonance imaging contrast agents, hyperthermal therapy agents, etc. In this review, we summarize the methods for preparing magnetic hydrogels. Then we give an overview ...[详细]

2016-06-27

A multifunctional statistical copolymer vesicle...

Abstract Multifunctional statistical copolymers can be simply synthesized in one step without tedious and time-consuming procedures. In addition, the fuzzy boundary between different functional groups in the statistical copolymers can facilitate the fabrication of new functional nanomaterials. Herein, we designed a novel multifunctional vesicle based on a statistical copolymer, poly[...[详细]

2016-06-15

Polymer vesicles: Mechanism, preparation, appli...

Abstract: Polymer vesicles, also known as polymersomes, are finding increasing applications in biomedical field, including drug delivery, gene therapy, magnetic resonance imaging, theranostics, etc. This is due to their intrinsic hollow nanostructure and compartmentalized domains with diverse functionalities. This review describes recent advances in the design and synthesis of poly...[详细]

2016-06-03

Synthesis and Mechanism Insight of a Peptide-G...

Abstract Atimicrobial resistance is an increasingly problematic issue in the world and there is a present and urgent need to develop new antimicrobial therapies without drug resistance. Antibacterial polymers are less susceptible to drug resistance but they are prone to inducing serious side effects due to high positive charge. Herein we report a peptide-grafted hyperbranched polyme...[详细]

2016-05-14

Light-triggered “on–off” switching of fluore...

Abstract We report a compound polymer micelle with light-triggered “on–off” switching of fluorescence based on the self-assembly of two block copolymers. First, the naphthalimide fluorophore is incorporated into poly(styrene-stat-naphthalimide)-b-poly(N-isopropyl acrylamide) [P(St-stat-MANI)-b-PNIPAM]. Second, the naphthopyran unit is engineered in poly(styrene-stat-naphthopyra...[详细]

2016-04-19

Asymmetrical polymer vesicles for significantly...

AbstractPolymer vesicles have wide applications in drug delivery, antibacterial and water remediation, etc. Theranostic polymer vesicles that can simultaneously deliver diagnostic and therapeutic agents, have been developed for more accurate diagnosis and more efficient cancer chemotherapy. Magnetic resonance imaging (MRI) is one of the most powerful and non-invasive clinical imaging modali...[详细]

2016-02-14

Ultrafine superparamagnetic iron oxide decorate...

AbstractMagnetic resonance imaging (MRI) is one of the most promising clinical imaging techniques in cancer diagnosis due to its high spatial resolution and non-invasive feature. Negative contrast agents such as superparamagnetic iron oxide nanoparticles (SPIONs) with large specific surface area and low cytotoxicity are able to shorten the transvers relaxation time T2, resultin...[详细]

2016-02-14

Multifunctional polymer vesicles for cancer ste...

Abstract Cancer stem cells (CSCs) are responsible for origin, growth, recurrence, and metastasis of tumor, and are closely linked to the failure of chemotherapy due to their self-renewal and multilineage differentiation capability with an innate resistance to cytotoxic agents. We have recently reported a novel EpCAM (epithelial cell adhesion molecule)-monoclonal-antibody-labeled CSCs-...[详细]

2016-01-11