Preparation of water dispersible poly(methyl me...

AbstractWe report a facile strategy for incorporating persistent and effective antibacterial property into a widely used polymer, poly(methyl methacrylate) (PMMA), by copolymerizing methyl methacrylate (MMA) with 2-(tert-butylamino)ethyl methacrylate (TA) in one pot via atom transfer radical polymerization (ATRP). The subsequent self-assembly of the resultant poly(methyl methacrylate)-b...[详细]

2015-10-10

Preparation of polymersomes in pure water for f...

Abstract We report a facile strategy for preparing persistent and effective antibacterial polymersomes (polymer vesicles) based on triblock copolymers synthesized by sequential copolymerization of 2-diethylaminoethyl methacrylate (DEA) and 2-(tert-butylamino)ethyl methacrylate (TA) via atom transfer radical polymerization (ATRP). The poly(ethylene oxide)-block-poly(2-diethylaminoethy...[详细]

2015-06-19

Rationally Separating the Corona and Membrane F...

AbstractIt is an important challenge to in situ grow ultrafine super-paramagnetic iron oxide nanoparticles (SPIONs) in drug carriers such as polymer vesicles (also called polymersomes) while keeping their biodegradability for enhanced T2-weighted magnetic resonance imaging (MRI) and drug delivery. Herein, we present a new strategy by rationally separating the corona and membrane functio...[详细]

2015-06-05

Disclosing the nature of thermo-responsiveness ...

AbstractThe apparent size increase of poly(N-isopropyl acrylamide) (PNIPAM)-basedpolymericmicellesuponheatingwasusuallyascribed to theirvolume growth or aggregation in aqueous solution. Herein we designed a photo-cross-linkable PNIPAM-based copolymer and proposed another thermo-responsive behaviour – fusion, which is disclosed by transmission electron microscopy (TEM) after in situ fix...[详细]

2015-06-01

EpCAM-Antibody-Labeled Noncytotoxic Polymer Ve...

Abstract:Cancer stem cells (CSCs) have the capability to initiate tumor, to sustain tumor growth, to maintain the heterogeneity of tumor, and are closely linked to the failure of chemotherapy due to their self-renewal and multilineage differentiation capability with an innate resistance to cytotoxic agents. Herein, we designed and synthesized a novel anti-EpCAM (epithelial cell adhesion...[详细]

2015-05-19

Rationally Engineering Dual Missions in One Sta...

Abstract:Effective inhibition of bacteria and removal of carcinogenic organic pollutants such as polycyclic aromatic hydrocarbons (PAHs) are important technical challenges in water purification because most of the traditional filter membranes are prone to being biologically contaminated by bacteria and difficult to filter off PAHs. Herein we present the synthesis and characterizat...[详细]

2015-04-17

Multifunctional Biocompatible and Biodegradable...

Abstract:Cancer patients after chemotherapy may also suffer bacterial attack due to badly decreased immunity. Although with high bacterial efficacy, conventional antibiotics are prone to inducement of drug resistance and may be not suitable for some cancer patients. In contrast, antibacterial peptides are highly effective in inhibiting bacteria without inducing resistance in pathogens. ...[详细]

2015-02-27

An Asymmetrical Polymer Vesicle Strategy for S...

Abstract:Traditional T1 magnetic resonance imaging (MRI) contrast agents such as diethylenetriaminepentacetatic acid (DTPA) chelated gadolinium [Gd(III)] have poor sensitivity, leading to a risk of accumulated toxicity in vivo. To significantly improve the sensitivity of a T1 MRI contrast agent and to enhance the efficacy of cancer chemotherapy, herein for the first time we report...[详细]

2015-01-22

A multifunctional azobenzene-based polymeric ad...

Abstract:The efficient removal of trace carcinogenic organic pollutants, such as polycyclic aromatic hydrocarbons (PAHs) and ionic dyes, from water is an important technical challenge. We report a highly effective recyclable multifunctional azobenzene (AZ)-based silica-supported polymeric adsorbent which can simultaneously remove both PAHs and anionic dyes from water to below parts per ...[详细]

2014-12-03

Silkworm cocoons by cylinders self-assembled fr...

Abstract:We report a novel silkworm cocoon-like nanostructure based on the 3D hierarchical self-assembly of cylinders which are spontaneously formed by an H-shaped polymer brush comprising a disulfide-bridged spacer and two brushes with alternating PEG and PCL side chains. Crystalline of PCL between adjacent cylinders bridges cylinders.文章链接：Polymer Chemistry​ 2015, 6, 8...[详细]

2014-11-21

Organic/Inorganic Composite Membranes Based on ...

Abstract:Fabrication of membranes with excellent biocompatibility and bioactivity remains an important technical challenge in bone tissue engineering. In this paper, poly(L-lactic-co-glycolic acid) (PLGA)–SBA15 (Santa Barbara Amorphous 15) composite membranes were prepared by using an electrospinning technique; PLGA was used as a biocompatible and biodegradable polymer and SBA1...[详细]

2014-11-14

Decoration of homopolymer vesicles by antibacte...

Abstract:Presented in this article is the proof of principle that silver nanoparticles can be decorated on homopolymer vesicles. The homopolymer vesicles are prepared by self-assembly of poly(2-(2-ethoxyethoxy)ethyl acrylate) (PEEA) in water/tetrahydrofuran (THF) solvent mixture. The –COOH end groups on the surface of the homopolymer vesicle facilitate the growth of ultrafine sil...[详细]

2014-08-26