Revisiting the time required for removing the u...

AbstractPresented in this abstract is the reconsideration of various important factors in the measurement of the drug loading content (DLC) and drug loading efficiency (DLE) based on an ‘instant’ biocompatible and biodegradable polymer vesicle which can be directly ‘dissolved’ in water, with a focus on the study of the time for removing the free drug. A detailed dialysis methodology...[详细]

2013-11-28

Antibacterial Polypeptide-Grafted Chitosan-Base...

Abstract：Antibacterial polypeptides as ancient immune defense systems are effective against bacteria. Here we report a novel kind of “armed” carrier: an antibacterial polypeptide-grafted chitosan-based nanocapsule with an excellent antibacterial efficacy against both Gram-positive and Gram-negative bacteria. This nanocapsule also has excellent blood compatibility and low cytotox...[详细]

2013-11-01

Homopolymer vesicles with a gradient bilayer me...

Abstract：We report an unusual homopolymer vesicle, which has a soft bilayer membrane composed of oligo(ethyleneoxy) side chains (OEs) with a gradually decreased packing density from the centre of the membrane to both margins, exhibiting thermo-responsive zeta potential and dispersibility and showing potential applications for anti-cancer drug delivery.文章链接：Chemical Commun...[详细]

2013-10-14

Silver-decorated biodegradable polymer vesicles...

Abstract：We report the first enzymatically degradable polymer vesicle decorated with silver nanoparticles, which showed low cytotoxicity against human normal liver L02 cells near the minimum inhibitory concentrations (MICs) but excellent antibacterial efficacy against both Gram-negative and Gram-positive bacteria with quite low MICs of 3.56 μg mL−1 and 7.12 μg mL−1, respective...[详细]

2013-08-19

Antibacterial high-genus polymer vesicle as an ...

AbstractPresented in this paper is an “armed” high-genus block copolymer vesicle (g = 18) which has excellent blood compatibility and more internal barriers than simple polymer vesicles (g = 0) for controlled anti-cancer drug delivery. The high-genus vesicle also shows better antibacterial activity against both Gram-positive and Gram-negative bacteria without quaternary ammonium moiet...[详细]

2013-08-06

Ultrasound and pH Dually Responsive Polymer Ves...

AbstractRecently, smart polymer vesicles have attracted increasing interest due to their endless potential applications such as tunable delivery vehicles for the treatment of degenerative diseases. However, the evolution of stimuli-responsive vesicles from bench to bedside still seems far away for the limitations of current stimuli forms such as temperature, light, redox, etc. S...[详细]

2013-07-08

Ultrafine silver nanoparticles with excellent a...

AbstractWe report a role-switching method for preparing ultrafine water-dispersible silver nanoparticles with long-term stability based on a soft deformable block copolymer vesicle. Those ultrafine silver nanoparticles showed excellent antibacterial efficacy against both Gram-negative and Gram-positive bacteria with quite low minimum inhibitory concentrations (MICs) of 16.9 μg mL...[详细]

2013-04-23

Acid and reduction dually cleavable amphiphilic...

AbstractDisulfide- and acetal-functionalized comb-like copolymers (SACP) with poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) side chains and a polymethacrylate backbone were synthesized and self-assembled for in vitro encapsulation and release of an anticancer drug, doxorubicin (DOX). Three step reactions including RAFT copolymerization of 2-hydroxyethyl methacrylat...[详细]

2013-04-17

Polymer/TiO2 Hybrid Nanoparticles with Highly E...

AbstractTiO2 nanoparticle has been considered as a safe sunscreen agent to reduce the skin cancer risk when exposed to sunlight. However, recently it was found that TiO2 particles accelerate the photodamage of skin due to their photocatalytic degradation activity. To effectively eradicate this unwanted effect, we present a new strategy toward the preparation of organic/inorganic ...[详细]

2013-01-09

Probing into Homopolymer Self-Assembly: How Doe...

AbstractSelf-assembly of amphiphilic homopolymers composed of both hydrophilic and hydrophobic components in each repeating unit is burgeoning in recent years due to their facile synthesis compared to block copolymers. However, ordered homopolymer nanostructures are very limited, and solid TEM evidence for the formation of vesicles and other complex morphologies is necessary to...[详细]

2012-12-13

pH-Sensitive Block Copolymer Vesicles with Var...

AbstractWe have previously reported the preparation of a novel pH-sensitive and biocompatible polymer vesicle in pure water based on the spontaneous self-assembly of a diblock copolymer, PMPC-b-PDPA, where PMPC is poly[2-(methacryloyloxy)ethyl phosphorylcholine] and PDPA is poly[2-(diisopropylamino)ethyl methacrylate] ( J. Am. Chem. Soc.2005, 127, 17982). Herein, we intend to repo...[详细]

2012-10-02

Antibacterial vesicles by direct dissolution of...

AbstractA novel thermo- and pH-responsive antimicrobial diblock copolymer has been synthesized and directly dissolved in water to form polymer vesicles upon simply raising the temperature. Compared to individual polymer chains, polymer vesicles exhibit much better antimicrobial efficacy against both Gram-negative and Gram-positive bacteria under physiological conditions with neith...[详细]

2012-09-25