Precise Synthesis of ABCDE Star Quintopolymers ...

AbstractA facile approach based on integrated utilization of ring-opening polymerization (ROP), reversible addition–fragmentation chain transfer (RAFT) process, and azide–alkyne cycloaddition reaction was efficiently used to construct amphiphilic 5-arm ABCDE star quintopolymers. The miktoarm stars are composed of poly(ethylene glycol) (A), poly(ε-caprolactone) (B), polystyrene (...[详细]

2012-09-07

Polymeric Micelles (Invited Book Section)

  AbstractMacromolecular self-assembly has provided a good means by which to selectively assemble polymers into well-defined nanostructures such as polymeric micelles, vesicles, and other morphologies. The polymeric micelles are good candidates for the application in drug delivery, gene delivery, and nanoreactors. In this review, the basic concepts and the recent advances in the preparation and...[详细]

2012-08-17

Water-dispersible and biodegradable polymer mic...

AbstractNew amphiphilic ABC triblock copolymers have been designed and self-assembled into water-dispersible and biodegradable polymer micelles, which exhibit good antibacterial activities without quaternary ammonium moieties or the loading of any external antibiotics due to the increased local concentration of cationic charge in the polymer micelles compared to the un-self-assembled ...[详细]

2012-05-16

Preparation of water-dispersible silver-decorat...

Abstract It is well known that silver nanoparticles have excellent antibacterial activities. However, to prepare well-defined, water-dispersible and long-term stable silver nanoparticles still remains insufficient. Presented in this paper are the design and preparation of new water-dispersible silver-decorated polymer vesicles and micelles based on a new kind of amphiphilic block-s...[详细]

2012-05-01

Multifunctional Polymer Vesicles for Ultrasensi...

Abstract Presented in this article is the synthesis of a new class of block copolymer, poly(ethylene oxide)-block-poly(tert-butyl acrylate-stat-acrylic acid) [PEO-b-P(AA-stat-tBA)], which can self-assemble into polymer vesicles with tuneable sizes at various conditions. The biocompatible and hydrophilic PEO chains form the vesicle coronas, while the PAA-stat-PtBA chains form the...[详细]

2012-04-24

Revisiting the time for removing the unloaded d...

AbstractPolymer vesicles have been widely explored as drug delivery carriers. However, there are still several notable problems in the determination of the drug loading content (DLC) and the drug loading efficiency (DLE) of the drug delivery vehicles. Presented in this paper is the reconsideration of various important factors in the measurement of the DLC and DLE based...[详细]

2012-03-13

pH-sensitive biocompatible block copolymer vesi...

AbstractHighly biocompatible pH-sensitive block copolymer vesicles can be prepared by the self-assembly of biocompatible block copolymers. Vesicle formation occurred spontaneously on adjusting the solution pH, with the hydrophobic chains forming the vesicle membrane and hydrophilic chains forming the vesicle coronas. The biocompatible vesicles can be used as drug carrier in pure wat...[详细]

2011-11-30

Self-Assembly of Hydrophilic Homopolymers: A Ma...

AbstractUnusual self-assembly behavior is observed for a range of hydrophilic homopolymers. This self-assembly behavior is contrary to the expected behavior of such hydrophilic polymers and instead mimics more commonly reported amphiphilic block copolymers. It is proposed that the unique combination of hydrophobic end groups at both the α and ω chain end accounts for this unusual self-a...[详细]

2011-06-07

pH-Responsive Chiral Nanostructures

AbstractThere is great current interest in the design of robust synthetic polymers for the preparation of novel functional, well-defined, biocompatible and tailorable materials for a range of possible applications. In this work we have used reversible addition fragmentation chain transfer (RAFT) polymerization to prepare chiral and responsive amphiphilic block copolymers (based on polypheny...[详细]

2011-05-29

Anisotropic particles with patchy, multicompart...

AbstractAnisotropic particles, such as patchy, multicompartment and Janus particles, have attracted significant attention in recent years due to their novel morphologies and diverse potential applications. The non-centrosymmetric features of these particles make them a unique class of nano- or micro-colloidal materials. Patchy particles usually have different compositional patch...[详细]

2011-03-08

Patchy multi-compartment micelles are formed by...

AbstractPatchy multi-compartment micelles are formed on direct dissolution of a primary amine-based triblock copolymer, poly(ethylene oxide)-b-poly(ε-caprolactone)-b-poly(2-aminoethyl methacrylate), PEO-b-PCL-b-PAMA, in water, with PCL chains forming the micelle cores and the PEO and PAMA chains forming phase-segregated patchy or hemispherical coronas. By selectively silicify...[详细]

2010-08-17

pH-Responsive Vesicles from a Schizophrenic Dib...

AbstractA novel tertiary amine and amino acid-based “schizophrenic” pH-responsive block copolymer, PDEA-b-PAP, has been synthesized by RAFT polymerization. By directly dissolving this copolymer in acid or basic aqueous solution block copolymer vesicles with switchable coronas and membranes were prepared. These novel assemblies were characterized using TEM, DLS, zeta potential, and SLS...[详细]

2010-05-18