pH-Sensitive Vesicles Based on a Biocompatible Zwitterionic Diblock Copolymer

作者:Jianzhong Du,Yiqing Tang,Andrew L,Lewis,Steven P. Armes 时间:2005-12-01 点击数:


Abstract

Highly biocompatible pH-sensitive diblock copolymer vesicles were prepared from the self-assembly of a biocompatible zwitterionic copolymer, poly[2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methacrylate], PMPC-b-PDPA. Vesicle formation occurred spontaneously by adjusting the solution pH from pH 2 to above 6, with the hydrophobic PDPA chains forming the vesicle walls. Transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and UV−visible absorption spectrophotometry were used to characterize these vesicles. Gold nanoparticle-decorated vesicles were also obtained by treating the vesicles with HAuCl4, followed by NaBH4.

文章链接:J. Am. Chem. Soc. 2005, 127, 17982-17983. [Selected as Chemical &       Engineering News 2005, 83(50), 8, ESI highly cited paper, as of Sep/Oct 2015]


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