Biomimetic pH-Sensitive Polymersomes for Efficient DNA Encapsulation and Delivery
作者：H. Lomas, I. Canton, S. MacNeil, J. Du, S. P. Armes, A. J. Ryan, A. L. Lewis, G. Battaglia 时间：2007-11-12 点击数：
Abstract
A novel gene delivery vector based on the ability of a synthetic amphiphilic block copolymer to mimic biological phospholipids by forming membrane-enclosed structures, specifically nanometer-sized vesicles, is presented. A pH-sensitive diblock copolymer forms vesicles (polymersomes) at neutral pH, and dissolves completely as unimers at endocytic pH (see figure). GFP-encoding plasmid DNA are successfully encapsulated inside the polymer vesicles, and delivered intracellularly.
文章链接：Adv. Mater. 2007, 19, 4238-4243. [ESI highly cited paper, as of Sep/Oct 2015; May/June 2017]
